Upon waking in the eerie, fog-enshrouded universe of Silent Siren, Dex Mercer finds himself holding a mysterious radio, guided by an unknown voice named Larse. With no memory of how he arrived, Dex is on a quest to uncover the chilling mysteries of the town and face the haunting truths of his past, all while the spectral voice of his wife, Mya, intermittently pierces the silence, guiding and haunting him through the mist.